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[DOI] [PubMed] [Google Scholar] 246.Abramek J., Bogucki J., Ziaja-Sołtys M., Stępniewski A., Bogucka-Kocka A
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This heightens susceptibility to the toxic effects of iron overload, disrupting intestinal mucosal homeostasis and triggering local inflammation and cell death, ultimately precipitating the onset of gut-associated diseases ( 2.2 Iron overload, deficiency, and IBD pathogenesis In the intestinal microenvironment of IBD, iron overload or functional iron deficiency not only serves as a source of oxidative stress but also acts as a critical factor triggering ferroptosis in intestinal epithelial cells